The Blues sit two points either side of their rivals, and victory in Wales will see the Stamford Bridge outfit capitalise on the result on Merseyside.
Head coach Garry Monk will be keen for his Swansea team to extend the gap above the relegation zone before the final three games of the season.
Swansea are six points above 18th-placed Fulham, but with the Cottagers hosting Norwich City on Saturday, it could become tight at the bottom.
Swansea City: DLLDWL
Possible starting lineups
Swansea City: Vorm; Rangel, Davies, Chico, Williams; Canas, De Guzman, Britton, Hernandez, Routledge; Bony
Chelsea: Cech; Ivanovic, Azpilicueta, Cahill, David Luiz; Matic, Ramires, Willian, Oscar, Salah; Ba
Sports Mole says: 1-2