The Blues are currently two points behind leaders Arsenal in the table following an impressive run both home and away.
Meanwhile, West Ham are in desperate need of the points as they battle against relegation.
The Hammers sit one point adrift of safety in the standings after six defeats from their last nine matches.
Chelsea romped to a comfortable 3-0 victory when the two teams met at Upton Park back in November.
Petr Cech, John Terry and Cesar Azpilicueta are expected to return for the hosts after the trio were rested for Sunday's win over Stoke City in the FA Cup. Fernando Torres remains sidelined with knee ligament damage.
West Ham: LLLWLL
Possible starting lineups
Chelsea: Cech; Ivanovic, Cahill, Terry, Azpilicueta; Ramires, David Luiz; Willian, Oscar, Hazard; Eto'o
West Ham: Jaaskelainen; Tomkins, Rat, Johnson, Taylor; Nolan, Morrison, Diarra, Diame, J Cole; Carroll
Sports Mole says: 2-0