The two sides meet in the UEFA Super Cup in Monaco and Simeone believes that his side can upset the Champions League winners despite being underdogs for the contest.
"I believe, when there is a favourite, it is because one is better than the other," Simeone told reporters. "I'd prefer to be the favourite because you have some assets the other doesn't - that is clear. But the game is what counts.
"What counts is what is on the pitch on Friday - sweat, heart, tears - things which go beyond what is on paper."