The highly-anticipated London derby carries a number of defensive injury concerns with it, as Spurs boss Harry Redknapp is likely to be without Younes Kaboul after the 26-year-old limped off the field with a knee injury during Tottenham's 2-1 defeat to Norwich City on Monday.
Scott Parker missed out on Spurs' defeat to the Canaries earlier this week with a hamstring problem, but is likely to return to the side for the match in the capital.
Meanwhile, Roberto Di Matteo will be forced to pick a team without Branislav Ivanovic due to the Serbian's three-match ban, which was confirmed by the Football Association after the Blues' failed to appeal a charge of violent conduct.
Tottenham: Friedel; Walker, Nelsen, King, Assou-Ekotto; Bale, Parker, Modric, Lennon; Van der Vaart; Adebayor
Chelsea: Cech; Bertrand, Cahill, Terry, Bosingwa; Ramires, Mikel, Lampard, Mata; Kalou, Drogba
Sports Mole says: 2-0