The Blues already have one foot in the next round courtesy of their 3-0 victory in the first leg last week, but they face a team that has scored 10 goals without reply in their three home games since returning from a winter break.
Chelsea also go into the match having seen a top-four spot taken out of their hands at the weekend courtesy of a 1-1 draw with Wolverhampton Wanderers.
Here, Sports Mole rounds up the latest injury and suspension news for Maurizio Sarri's side.
CHELSEA'S INJURY LIST
Status: Slight doubt
Type of injury: Illness
Possible return date: March 17
There is a minor concern over the fitness of Higuain, who is struggling with an illness and could be rested for Thursday's match as a result.
Type of injury: Knee
Possible return date: Unknown
Chelsea's top-four hopes may not have made it through the weekend unscathed, but Sarri's players did and long-term absentee Marco van Ginkel remains the only player ruled out completely.
CHELSEA'S SUSPENSION LIST
Chelsea have no players suspended for this game.