Lampard was on the bench for Saturday's 1-0 defeat at Aston Villa in the Premier League, while Eto'o was left out of the squad completely.
Meanwhile, Didier Drogba starts up front for Galatasaray as he returns to Stamford Bridge for the first time since leaving Chelsea two years ago.
Chelsea: Cech; Ivanovic, Cahill, Terry, Azpilicueta; Ramires, Lampard, Willian; Oscar, Hazard, Eto'o
Subs: Schwarzer, David Luiz, Torres, Mikel, Schurrle, Ba, Kalas
Galatasaray: Muslera; Eboue, Semih, Chedjou, Telles; Yekta, Melo, Selcuk; Sneijder; Burak, Drogba
Subs: Ufuk, Burdisso, Ceyhun, Hajrovic, Umut, Hakan, Sabri Sarıoglu
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