The two sides have met just once before in a competitive clash, with Chelsea 3-0 winners in Paris during the group stages of the 2004-05 campaign in what was Jose Mourinho's first ever European game in charge of the Premier League outfit.
PSG's overall record against English opposition is disappointing with just one win from their seven matches, losing three times in the process. That said, Chelsea's success over PSG in 2004 has been their only triumph on French soil to date.
PSG, who were eliminated in the quarter-finals of the Champions League by Barcelona last season, overcame Bayer Leverkusen in the previous round to set up the clash with Chelsea. The French side are also unbeaten in their last 28 home matches in Europe and have won their last seven in Ligue 1, with that run of form leaving them 13 points clear at the top of their domestic table.
Chelsea, meanwhile, overcame Galatasaray 3-1 on aggregate in the previous round. The Blues have been in the semi-finals of the competition in seven of the last 11 seasons, but they enter the match off the back of a 1-0 defeat to Crystal Palace in the Premier League.
Should Chelsea capture the Champions League this season, Mourinho would become the first manager to win the European Cup with three different teams.
The home side have no injury concerns from their 1-0 win over Nice at the weekend, while Laurent Blanc also has a clean list in terms of suspensions.
Chelsea, however, will be without the services of Samuel Eto'o, who remains on the sidelines with a hamstring injury. Ashley Cole (knee) is also out, but Frank Lampard is expected to feature as Mourinho looks to his experienced players for the European clash in Paris.
January signing Nemanja Matic is ineligible after featuring for Benfica in Europe in the early stages of the season. As a result, John Obi Mikel could come into the centre of midfield, but Brazilian international Oscar is expected to start on the bench once more.
Possible starting lineups
PSG: Sirigu; Jallet, Silva, Alex, Digne; Verratti, Matuidi, Cabaye; Cavani, Ibrahimovic, Lavezzi
Chelsea: Cech; Ivanovic, Terry, Cahill, Azpilicueta; Ramires, Lampard, Mikel; Hazard, Torres, Schurrle
Sports Mole says: 2-1