The sides go head-to-head in the French capital on April 2, and the Portuguese coach thinks that the Ligue 1 leaders have the advantage ahead of the tie.
He told RMC: "Paris is a team with very good players. Paris is already a champion and this is an important advantage. They already think about Chelsea and not Nice [on Friday].
"For us, it is different in the Premier League. All matches are a final for us. Against Crystal Palace [on Saturday] it will be a final.
"Paris is the favourite thanks to this small advantage. They have no experience in the Champions League but have quality players. They have an outstanding attack and this is very important."
Chelsea are currently top of the Premier League, while PSG hold the same spot in their domestic league.