The Ukrainian champions defeated the Premier League outfit 2-1 at home two weeks ago, and Lucescu is confident that they can score a double over the Blues.
"We have prepared well," he said. "We are in good form too. Our players are also thinking of this game as a very important match for us – for the three points, for remaining at this level.
"It's not every year you can play against teams like Juventus or Chelsea.
"I prepare my players knowing very well that absolutely all teams can be beaten – even Chelsea at home."
Shakhtar are currently at the top of Group E with seven points from three matches.