The striker was dropped to the bench for Celtic's opening match of the competition against Benfica last month.
Captain Scott Brown has also been passed fit following a hip problem.
Hosting Spartak have included former Celtic winger Aiden McGeady among their starting players.
Spartak: Pesyakov; Insaurralde, Pareja, Makeev, Carioca; McGeady, De Zeeuw, Kallstrom, Kombarov, Ari; Emenike
Celtic: Forster; Lustig, Wilson, Ambrose, Izaguirre; Commons, Brown, Wanyama, Mulgrew; Samaras, Hooper