Dougie Freedman's side have won seven of their last nine league games to move to within two points of the playoff places.
O'Driscoll, whose side prop up the table and are eight points adrift of safety, has claimed that Bolton will provide a different test compared to other teams Bristol have faced.
"This will be arguably the most difficult game we have had at home," O'Driscoll told the club's official website.
"They have put together a good run of form, but time will tell if it is at the right or wrong time.
"They have a different approach from some of the other teams that have come to Ashton Gate. They have a lot of options and are fluid in possession of the ball, as well as being mobile in attack."
Bristol play Bolton on Saturday afternoon.