Blackpool make the long trip to the South Coast unbeaten in their last five matches, but Paul Ince's men are four points clear of the relegation zone.
Poyet has no fresh injury worries ahead of the game and he could name the same XI which started the match against Peterborough. Tomasz Kuszczak is expected to retain his place in goal at the expense of Casper Ankergren.
Paul Ince has Isaiah Osbourne available for selection after serving his three-match ban.
Possible starting lineups
Brighton: Kuszczak; Greer, Calderon, Upson, Bridge; Crofts, Orlandi, Hammond, Lopez, Bridcutt; Ulloa
Blackpool: Gilks; Crainey, Basham, Cathcart, Sylvestre; Phillips, Ferguson, Broadfoot, Baptiste, Ince; Delfouneso
Sports Mole says: 2-1