Brazil needed penalties to reach the last eight in their previous match against Chile, and come up against another of their South American rivals in the quarter-finals.
Luis Felipe Scolari will be without Luiz Gustavo, who is suspended after picking up his second booking of the tournament.
There are no such concerns for Colombia, who have reported no fresh injuries following their last-16 clash with Uruguay.
James Rodriguez, who currently leads the race for the golden boot with five goals, is expected to continue, while captain Mario Yepes appears to have put the thigh problem that hampered him earlier in the tournament behind him.
In the 12 previous meetings between these two sides, Brazil have won seven, while the other five have ended in a draw.
Possible starting lineups
Brazil: Cesar, Alves, Silva, Luiz, Fernandinho, Marcelo, Hulk Fred, Willian, Neymar, Oscar,
Colombia: Ospina, Zuniga, Armero, Sanchez, Zapata, Yepes, Cuadrado, Aguilar, Gutierrez, Rodriguez, Martinez
Sports Mole says: 1-2 AET.
Check out what the Sports Mole Sofa panel thinks of this clash below: