The Seasiders, who have struggled to sign new players during the current transfer window, have lost both of their league matches so far this season.
The manager has insisted that he still wants to bring in more players before the end of the month, but it is not clear whether they will be arriving in time for this fixture.
Meanwhile, Brentford will be looking to capitalise on Blackpool's woes after being edged out by Bournemouth on Saturday.
This will be the first meeting between these two sides since 2007, when Brentford ran out 3-1 winners.
Possible starting lineups
Blackpool: Lewis; Oriol, McMahon, Clarke, Daniels; Perkins, Zoko, Lundstram; Cywka, Delfouneso, Ranger
Brentford: Button; McCormack, Bidwell, Douglas, Tarkowski; Craig, Jota, Pritchard, Gray; Proschwitz, Judge
Sports Mole says: 1-1