Appleton oversaw his first match at Ewood Park on Saturday, but he could not stop Rovers slipping to a 2-1 defeat to Charlton Athletic.
Victory for Brighton could move them to within two points of the playoff places.
The original fixture between these two teams was called off at the end of December due to a waterlogged pitch.
Meanwhile, new signing Leonardo Ulloa may be available for the visitors, subject to international clearance.
Blackburn: Kean; Mn Olsson, Dann, Kane, G Hanley; Lowe, Murphy, Vukcevic, Rochina; Rhodes, Kazim-Richards
Brighton: Kuszczak; Greer, El-Abd, Calderon, Bridge; Hammond, Orland, Buckley, Bridcutt; Barnes Mackail-Smith
Sports Mole says: 1-2