The current holders of the trophy have won all three of their Group C matches thus far and thrashed Plzen 5-0 in the reverse fixture at the Allianz Arena a fortnight ago.
Mario Gotze scored after coming off the bench in that match and started in the 2-1 victory over Hoffenheim on Saturday, but is likely to be only among the substitutes should Arjen Robben recover from injury in time.
Gotze, a £30m summer signing from Borussia Dortmund, has only been used three times from the start this season, with Robben and fellow winger Franck Ribery keeping him out of the team with their impressive performances.
The Spanish coach may rotate his defensive options against a side who are yet to claim a point in this year's competition and have won just one of their last five matches in all competitions.
Captain Pavel Horvath scored twice as Plzen returned to form with a 6-0 win in the domestic league on Friday and will likely play in midfield - in front of experienced Czech international David Limbersky.
Possible starting lineups
Plzen: Kozacik; Limbersky, Hubnik, Cisovsky; Horava; Horvath, Prochazka, Petrzela, Rajtoral; Tecl, Duris
Bayern: Neuer; Rafina, Dante, Van Buyten, Contento; Schweinsteiger, Alaba; Ribery, Muller, Robben, Mandzukic
Sports Mole says: 0-4