Deschamps will be without goalkeeper Steve Mandanda through suspension, while Souleymane Diawara is ruled out with a knee problem.
Striker Loic Remy has also been rated doubtful for the clash because of a persistent knee complaint.
The game is likely to come too soon for Bayern midfielder Bastian Schweinsteiger, who has been struggling with a knee injury.
However, Thomas Muller has been deemed fit and should start in a wide attacking role at Stade Velodrome.
Tomorrow's match will be the first official meeting between the two sides.
Marseille: Bracigliano; Azpilicueta, M'Bia, N'Koulou, Morel; Diarra, Cheyrou, Amalfitano; Valbuena, Brandao, A. Ayew
Bayern: Neuer; Lahm, Boateng, Badstuber, Alaba; Luiz Gustavo, Kroos; Robben, Müller, Ribery; Gomez
Sports Mole says: 1-2