Defeats to Valencia and BATE Borisov have left the former French champions bottom of Group F after two matches and defeat at home to Bayern could end their campaign.
Bayern, meanwhile, currently sit third in the group having beaten Valencia and lost to BATE Borisov, but they have won all nine of their Bundesliga matches so far this season.
Lille have lost three of their last four Champions League matches, but they face a Bayern side that has lost four of their last five away games in Europe.
Bayern Munich: WWLWW
Lille: Landreau; Beria, Basa, Chedjou, Digne; Pedretti, Balmont; Kalou, Martin, Payet; Roux
Bayern Munich: Neuer; Lahm, Boateng, Badstuber, Alaba; Martinez, Schweinsteiger; Muller, Kroos, Ribery; Mandzukic
Sports Mole says: 1-2