As it stands, with six matches left to play, the Clarets are 10 points clear of their nearest challengers Queens Park Rangers.
Danny Wilson's charges currently occupy the final relegation place and are two points adrift of Charlton Athletic in 21st, having also played one game more than the South Londoners.
The hosts will be without Kelvin Etuhu for the visit of Burnley because of suspension, while Norwegian international striker Marcus Pedersen has been suffering with a hamstring complaint of late and could also miss out.
In total, Burnley have won just nine of their 33 trips to Barnsley, with the home team having recorded 14 victories.
Possible starting lineups
Barnsley: Steele; Nyatanga, M'Voto, Kennedy, Ramage; Dawson, Jennings, Cywka, Lawrence, McLaughlin; O'Grady
Burnley: Heaton; Baird, Mee, Edgar, Duff, Shackell; Kightly, Jones, Treacy; Barnes, Arfield
Sports Mole says: 1-1