The Spanish champions suffered a 2-0 loss at Granada on Saturday night to stay in eighth position in the table - one spot and one point behind Villarreal, who have made a solid start to the 2019-20 campaign.
Barca's loss at Granada on Saturday means that the Spanish champions have made their worst start to a league season for 25 years - Ramon Azeez and Alvaro Vadillo scored the goals for the home side, and it is difficult to argue against the final result as Ernesto Valverde's side were desperately poor on the night.
Not only have Barca taken just one point from their three away games this season, they have failed to win any of their past seven matches on their travels in all competitions, which will be a serious concern at this stage.
The Catalan giants were fortunate to pick up a point in their Champions League opener against Borussia Dortmund last week as Marco Reus missed a penalty for the Bundesliga outfit, who had the better chances.
Lionel Messi has come off the bench in Barca's last two matches after recovering from a calf problem, and it seems likely that the Argentine will be thrust into action on Tuesday night. Ideally Valverde would take his time when it comes to re-introducing his star man, but the La Liga champions have struggled without him.
Barca's away form has been poor, but Valverde's side have won both of their La Liga games on home soil this season - beating Real Betis 5-2 on August 25 before recording the same scoreline against Valencia in their first match after the recent international break.
What's more, Barca are only four points off the top of the table as things stand with a number of teams struggling for consistency early on. Indeed, Atletico Madrid have won three, drawn one and lost one to collect 10 points, while Athletic Bilbao actually lead the way after five games of the 2019-20 campaign.
Real Madrid have had their problems this season, but Zinedine Zidane's side recorded a huge 1-0 win at Sevilla on Sunday night to move into second spot; it is a bunched up league at the moment, though, and Barca will still be fully confident in their chances of retaining the Spanish title.
It is an interesting period of the season for the Catalan giants as they face Villarreal and Getafe in their next two league fixtures before welcoming Inter Milan in the Champions League on October 2. Sevilla will then visit Camp Nou in La Liga on October 6 as the big matches continue to arrive.
Recent form: LWDWL
Recent form (all competitions): LWDWDL
Two wins, two draws and one defeat - that is how Villarreal have performed in their opening five league games of the season. A total of eight points has left them in seventh position in the table, while they are the joint-leading scorers in the division alongside Barca with 12 goals to show for their troubles.
The Yellow Submarine actually failed to win in their first three matches - drawing 4-4 with Granada on the opening weekend before losing to Levante. That said, they picked up a welcome point at home to Real Madrid on September 1 before two impressive victories over Leganes and Real Valladolid.
Indeed, Javi Calleja's side won 3-0 at Leganes before a 2-0 victory over Valladolid on Saturday, meaning that they will travel to Camp Nou full of confidence and looking to capitalise on Barca's obvious problems.
Last term was a huge disappointment for Villarreal as they finished the season in 14th, which actually represented their lowest position since 2011-12. Indeed, finishes of sixth, sixth, fourth, fifth and fifth preceded what was a poor 2018-19 season for a club of their calibre.
Only the three relegated clubs - Girona, Huesca and Rayo Vallecano - won fewer league games than Villarreal (10) last term, although there have been plenty of positive signs over the last few weeks.
The last clash between Villarreal and Barca actually finished 4-4 at the Estadio de la Ceramica earlier this season, but the Catalan giants have won each of the last eight La Liga meetings between the two sides at Camp Nou. Indeed, not since 2010 have the Yellow Submarine avoided defeat in this particular fixture.
Meanwhile, Villarreal's last away league victory over Barca came in 2008, which is an indication of the size of the task facing the visitors on Tuesday night. What's more, as touched on above, Barca's home form has not been the issue this season - scoring 10 in their two fixtures in front of their own supporters.
No player has scored more times in Spain's top flight this season than Villarreal's Gerard Moreno, though, and the 27-year-old will be fired-up to face Barca due to his connections with their Catalan rivals Espanyol.
Recent form: DLDWW
Ousmane Dembele has made good progress in his recovery from a hamstring issue, and there are suggestions that the France international could make his return on Tuesday night.
Barcelona possible starting lineup:
Ter Stegen; Roberto, Pique, Lenglet, Semedo; Arthur, Busquets, De Jong; Messi, L Suarez, Griezmann
Villarreal possible starting lineup:
Asenjo; Quintilla, Torres, Albiol, Pena; Iborra, Cazorla, Gomez; Chukwueze, Moreno, Ekambi
Head To Head
As mentioned above, the two teams played out a 4-4 draw in their last clash back in April, with Messi and Luis Suarez scoring late to see Barca claim a point on their travels.
Barca have won each of the last eight La Liga meetings between the two sides at Camp Nou, though, including a 2-0 victory in the corresponding game during the 2018-19 campaign.
Villarreal's last La Liga success at Camp Nou was back in March 2008 when former Denmark international Jon Dahl Tomasson scored the winner against a Barca side that included the likes of Thierry Henry, Ronaldinho, Andres Iniesta and Samuel Eto'o.
We say: Barcelona 3-1 Villarreal
There have been plenty of goals in the recent meetings between the two teams, making a low-scoring affair on Tuesday night even more unlikely. Neither side has struggled to find the back of the net this season, but we fancy Barca to have enough firepower to pick up a much-needed three points.
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