The Catalan side, who have won their last six league games, sit joint-top of the league table alongside Atletico Madrid.
Valladolid have drawn three and lost one of their last four games after holding Malaga to a 2-2 draw last weekend.
Valladolid coach Juan Ignacio Martinez has no injury concerns and could name the same side that drew with Malaga.
Possible starting lineups
Barcelona: Valdes; Alves, Bartra, Pique, Adriano; Busquets, Xavi, Iniesta; Neymar, Fabregas, Pedro
Valladolid: Marino; Rukavina, Rueda, Valiente, Pena; Ebert, Sastre, Baraja, Rama; Osorio, Guerra
Sports Mole says: 3-1