The La Liga leaders go into the match at the Estadio Municipal de Riazor having not been beaten this season.
Despite their storming start to the campaign, Vilanova believes that his team will face a stern test from their hosts.
"There are no easy games and certainly not away to Deportivo - especially with the players coming off the international break," he said. "Riazor has never been an easy ground."
Deportivo currently sit 18th in the table following just one win from their opening seven matches.