The reigning champions were forced to settle for a point in the 1-1 draw against local rivals Espanyol.
The result allowed Real Madrid to extend the gap at the top of the table, leaving the pressure on the Catalan giants to respond. Guardiola has said that the three points are a "minimum expectation" for the club.
"In football something always happens if you don't win, and even more so for those in the big clubs," Guardiola said.
"So against Betis we have to win just like against Osasuna, we went there to win.
"But there still remain 63 points to play for. That's still a lot of points and the objective I have in my head which I need to transmit to the players is that we have to win these points. We have to do that."
Barcelona sit eight points behind leaders Real Madrid with a game in hand.