The two sides played out a 2-2 draw in the first leg of their quarter-final clash last week, but Barcelona will be confident of advancing into the next round having won each of their last six Champions League quarter-finals.
The home side enter the match on the back of a thumping 5-0 win over Real Mallorca at the weekend, while PSG also continued their pursuit of the Ligue 1 title with a 2-0 victory over Rennes, making it three wins from their last four league matches.
Lionel Messi is not expected to recover in time to start the match, but could be named on the bench by boss Tito Vilanova. His spot in the team should go to Cesc Fabregas, fresh off the back of a hat-trick against Mallorca at the weekend.
Carlos Puyol and Javier Mascherano are also both injured, meaning that Alex Song could drop into the defence alongside Gerard Pique. Meanwhile, Alexis Sanchez and David Villa are also both expected to start.
PSG boss Carlo Ancelotti, meanwhile, is expected to recall Marco Verratti at the expense of David Beckham, but Maxwell should continue at left-back, with Mamadou Sakho having to make do with a place on the bench.
Barcelona: Valdes; Alves, Pique, Song, Alba; Xavi, Iniesta, Busquets; Sanchez, Fabregas, Villa
PSG: Sirigu; Jallet, Silva, Alex, Maxwell; Lucas, Verratti, Matuidi, Pastore; Lavezzi, Ibrahimovic
Sports Mole says: 3-1