The Spanish champions have taken 10 points from their five group matches, but defeat in their final fixture could drop them to second in the section if AC Milan beat Ajax on the same evening.
The Catalan outfit were victorious in the reverse fixture in Scotland, but they needed a late header from Cesc Fabregas to collect all the points in a tight affair.
The La Liga leaders will also enter the match boasting an impressive home record in this competition, having lost just one of their last 24 European games at Camp Nou.
Celtic, meanwhile, will finish bottom of Group H regardless of their result in Spain. The Scottish outfit have taken just three points from their five matches, losing four times in the process.
The home side are still without the services of first-choice goalkeeper Victor Valdes, with the Spaniard out with a calf injury.
Meanwhile, Celtic boss Neil Lennon has no fresh injury concerns ahead of the clash. Anthony Stokes is expected to be joined in attack by Georgios Samaras, while Kris Commons, fresh from his double against Motherwell in the league at the weekend, will start in midfield.
Possible starting lineups
Barcelona: Pinto; Alves, Pique, Mascherano, Adriano; Busquets, Xavi, Iniesta; Neymar, Fabregas, Sanchez
Celtic: Forster; Izaguirre, Mulgrew, Lustig, Ambrose; Brown, Ledley, Commons, Pukki; Stokes, Samaras
Sports Mole says: 3-0