The Blaugrana will head into the second leg of their last-16 clash at Camp Nou 2-0 down from the first leg played at the San Siro last month.
"The Champions League is the most important title," he told reporters. "It's the one that every player craves.
"There are no nerves, we are just going to try and take the game to Milan. The win over Deportivo gives us confidence."
Barcelona warmed up for the match with a 2-0 home victory over Deportivo La Coruna in La Liga on Saturday.