The two sides played out a 1-1 draw in the first leg at the Camp Nou last week – a result that handed Atletico a slight advantage entering the clash at the Vicente Calderon.
"Atletico will be ready for the game against Barcelona. We are high on confidence following the good results," he told Marca.
"We want to find right until the end and see how far we can go. We are all very pleased with what we have done so far. This season might seem like a dream, but it's actually reality.
"This is the result of a lot of hard work over the years. We have worked hard and are brimming with confidence. We all know how important this game is both for the club and for the fans. We are all determined to do well."
Atletico have not yet been beaten in this season's Champions League.