The 26-year-old featured for the Spanish champions at Parkhead last season as they were famously beaten 2-0 by the Hoops.
Despite his side being the heavy favourites to win the Group H fixture this time around, Fabregas believes that it will still be a tough match.
"I played here with Arsenal as well and it is difficult," BBC Sport quotes him as saying. "They are always behind their team. They take a corner and it feels like a goal."
Barca reached the semi-finals of last season's competition before they were hammered 7-0 on aggregate by eventual winners Bayern Munich.