Los Colchoneros' defence of the trophy ended against Rubin Kazan, despite them winning 1-0 in Russia.
Meanwhile, 12th-placed Espanyol currently top the form table in Spain having taken 16 points from the last 18 available.
Last week's 1-0 win over Real Betis was their third in a row.
Atletico: Asenjo; Juanfran, Godin, Diaz, Luis; Suarez, Tiago; Rodriguez, Turan; Adrian; Falcao
Espanyol: Casilla; Colotto, Moreno, Capdevilla, Forlin; Simao, Verdu, Sanchez, Lopez; Garcia, Stuani
Sports Mole says: 1-0