Madrid struggled without the services of their star player Radamel Falcao but they will be confident of recording a victory over Real Betis after they recently knocked them out of the Copa del Rey.
Madrid won their home leg against Betis 2-0 and they will be favourites to dispatch a side that have up to half a dozen players missing through injury.
Betis are also without a victory in four matches and they were comfortably beaten 3-0 by league rivals Rayo Vallecano last week.
Atletico Madrid: WWDLW
Real Betis: WDLLD
Possible starting lineups
Atletico Madrid: Courtois; Juanfran, Filipe Luis, Diaz, Godin; Tiago, Belozoglu, Raul Garcia, Turan; Rodriguez, Diego Costa
Real Betis: Adrian; Perquis, Nacho, Javi Chica, Antonio Amaya; Salva Sevilla, Benat, Canas, Ruben Castro; Jorge Molina, Molins
Sports Mole says: 3-1