With Real not playing until Sunday evening, Atletico will move level on points with Jose Mourinho's side if they defeat struggling Granada.
The hosts, who have won twice in their last six games to fall three points behind Real, drew 0-0 against Getafe last time out.
Granada have not won since their 3-0 victory over Deportivo La Coruna on February 9. They have drawn two and lost five of their seven matches since. Last Friday's 5-1 defeat at home to Real Betis leaves Lucas Alcaraz's side 16th in the La Liga table, two points clear of the relegation zone.
Alcaraz may be tempted to make changes to the Granada side beaten by Betis, with Diego Buonanotte in contention to start.
Possible starting lineups
Atletico: Courtois; Manquillo, Miranda, Godin, Filipe Luis; Koke, Suarez, Gabi, Garcia; Costa, Falcao
Granada: Tono, Siqueira, Mainz, Lopez, Ortiz; Buonanotte, Rico, Santos, Nolito, Brahimi; Aranda
Sports Mole says: 3-1