Los Rojiblancos currently lead the way in La Liga, one point clear of Barcelona and three above Real Madrid with just six games remaining in the campaign.
However, Simeone believes that each one of those matches will be tough for his side, especially a potential title-decider on the final day when they face Barcelona at the Camp Nou.
"I can't imagine an easy game seeing what's ahead of us. Getafe and Elche, Malaga with their needs, Valencia and Levante. And you know about the last one," Simeone told the club's official website.
Atletico's next match comes in the Champions League as they look to progress past Barcelona and into the semi-finals with the tie perfectly poised after a 1-1 draw in the first leg.