Atletico travel to Seville currently sitting second in La Liga, but victory would move them top before Real Madrid welcome Barcelona to the capital in the late start on Sunday.
"Every game is vital between now and the end of the season. It will be a good game and complicated, because they're playing for their lives and we're challenging for the title," he told reporters at a press conference.
"We're expecting to see the best of Atletico, because it's an important game for us.
"Whatever happens in that game, what matters most is that we win ourselves. It's all the same to us and whatever happens, it will be fine so long as we win at Real Betis."
Atletico travel to Barcelona on the final weekend of the season.