The home side dominated proceedings in the opening period, but they could not find the back of net, with Diego Costa firing the best chance wide of the target.
The second period brought three red cards, three penalties and three goals in a quite stunning half of Copa del Rey football.
Costa sent the home side ahead from the spot early in the half, but Alvaro Negredo converted moments later to level proceedings.
There was time for Costa to score another penalty, however, to leave Atletico with a 2-1 advantage over nine-man Sevilla ahead of the second leg.
Read how it all unfolded in Sports Mole's minute-by-minute live commentary of the action below.
ATLETICO: Courtois; Juanfran, Miranda, Godin, Luis; Gabi, Suarez, Koke, Turan; Adrian, Costa
SEVILLA: Beto; Maduro, Navarro, Spahic, Fazio, Cicinho; Navas, Kondogbia, Medel, Rakitic; Negredo