The Belgium international will miss the rest of the season and the World Cup in Brazil after rupturing his Achilles in training last week.
In the striker's absence, Holt is hopeful that he can get more playing time following his first Villa goal in Saturday's 2-1 defeat to Fulham.
"I've been waiting to play and you don't want minutes because of what's happened but when it comes it's an opportunity to rise up and put a performance in," the Birmingham Mail quotes Holt as saying. "The only thing which bothers me is what the other ten people on the team with me think."
Holt has started twice and made five substitute appearances since signing for Villa on a short-term loan from Wigan Athletic in January.