The French club returns to European action for the first time since 2006 after securing a second-placed finish in the Ligue 1 table last season.
Meanwhile, Leverkusen are currently at the top of the Bundesliga standings with two wins and a draw from three matches.
Lacina Traore remains sidelined for Monaco, while Leverkusen have no fresh injury concerns ahead of the match.
Bayer Leverkusen: WWWWDD
Possible starting lineups
Monaco: Subasic; Dirar, Raggi, Carvalho, Kurzawa; Moutinho, Toulalan, Kondogbia; Ferreira Carrasco, Berbatov, Ocampos
Bayer Leverkusen: Leno; Jedvaj, Toprak, Spahic, Boenisch; Castro, Bender; Bellarabi, Calhanoglu, Oztunali; Kiessling
Sports Mole says: 0-2