The Cottagers are just one place behind their rivals on goal difference having put together an unbeaten run of four matches.
Arsenal will be keen to get back in the winning habit following last weekend's demoralising defeat to Manchester United as well as letting a two-goal lead slip in their midweek draw at Schalke in the Champions League.
Aaron Ramsey is expected to be ruled out as he recovers from a groin problem, while Fulham have no new injury concerns ahead of the match.
Arsenal: Mannone; Sagna, Mertesacker, Vermaelen, Santos; Arteta, Djourou; Walcott, Cazorla, Podolski; Giroud
Fulham: Schwarzer; Riise, Hangeland, Baird, Hughes; Riether, Duff, Diarra, Kacaniklic; Berbatov, Ruiz
Sports Mole says: 2-1