The Bulgarian has scored 13 Premier League goals since moving from Manchester United in the summer, including the winner against Tottenham Hotspur at White Hart Lane last month.
The Gunners will be looking for three points as they continue on their quest for Champions League qualification, but the French coach expects a tough challenge in West London.
"They are a good side who everybody takes seriously," Wenger told reporters. "They have a good technical level. Martin Jol plays with good football philosophy.
"Berbatov is at the heart of their creative side. He can score and he can provide so it's important that we keep him very quiet, but Bryan Ruiz did well the other night, Steven Sidwell played well too and they were very solid at the back."
The North London side are currently fourth in the Premier League, two points ahead of Spurs.