The 22-year-old, who started his career with the Welsh outfit, has often been subjected to a hostile reception from Swansea City fans due to his association with the Bluebirds.
Nevertheless, the Wales international scored in the Gunners' 1-2 victory at the Liberty Stadium earlier this season, and Wenger has warned City's fanbase that they could be silenced in a similar fashion should they boo the midfielder.
Speaking to The Mirror, the Frenchman said: "At Swansea [the boos] inspired him. The first time it happened it affected him, now he takes that in a more positive way.
"I don't think he will get a hostile reception, not at Cardiff, I don't think he will.
"He got a hostile reception at Swansea because, like everywhere in the world, Swansea hates Cardiff and Cardiff hates Swansea."
The Welshman enjoyed a one-month loan spell at his former club in 2011 as part of his rehabilitation for the long-term injury sustained at Stoke City the previous year.
Today's clash at the Cardiff City Stadium is scheduled to kick off at 3pm.