The Gunners midfielder, who has had his career blighted by a succession of problems over the past few years, played in an unfamiliar holding role as the Three Lions recorded a 2-0 win over Switzerland on Monday evening.
Neville thinks that Wilshere can finally start to realise his full potential on the international stage if he manages to avoid any more lengthy spells in the treatment room.
He told talkSPORT: "[Wilshere's] got the mental strength to be a top international player and he's got the talent, but what he needs to do now is to physically make sure he keeps completely free of injury for a long period of time.
"I know he's said since the game he was looking at clips of Andrea Pirlo. Of course, I played with Paul Scholes and if you look at those two, you wouldn't normally have them down as the holding midfield player type."
England play San Marino on October 9 at Wembley.