The German defender will come up against the tallest striker in the Premier League this weekend when he faces up to the challenge of Stoke forward Peter Crouch.
Mertesacker is convinced that his team are capable of dealing with Stoke and getting a positive result at the Britannia Stadium.
He told the club's official website: "We have to switch on quickly and do the right thing. We have done a lot of things concerning set pieces, throw-ins and crosses.
"We have to cover each other even more than the other games because they are very dangerous players, especially up front, and very tall players. Maybe we have to behave differently but we always want to show our own qualities.
"I played against Crouch at Wembley so it is not a new situation. When you look at Sunderland and Stephane Sessegnon and then one week later you play against Crouch, it's weird but you have to deal with this."
Arsenal are looking for their first win at the Britannia since 2010 when they meet Stoke on Sunday.