Back in September, Spanish attacker Cazorla claimed his first goal for the Gunners as they eased to a 2-0 win over the Reds at Anfield.
However, this time around Cazorla believes that the Merseysiders will be a different proposition.
"It was a nice goal, one that I will always remember, my first with Arsenal and in a stadium that's very special like Anfield," he told Arsenal's matchday programme.
"We put in a good performance against them. Also, they were at an early stage. They had good players but were quite dependent on Luis Suarez in terms of scoring.
"Now, they have Daniel Sturridge and Steven Gerrard is a spectacular player. They have gained in confidence and I think it'll be a totally different game."
Cazorla has been tipped to be given a place in the Arsenal starting lineup tonight.