Lukasz Fabianski returns in goal at the expense of Wojciech Szczesny, while Carl Jenkinson, Alex Oxlade-Chamberlain and Yaya Sanogo are also in the starting XI for the Wembley clash against the current cup holders.
Wigan's Ben Watson, who scored the winner in last season's final against Manchester City, is out with a broken leg.
The Latics, who have never played Arsenal before in the FA Cup, are unbeaten in their last 12 matches in this competition, winning 10 and drawing two.
Wigan Athletic: Carson, Perch, Boyce, Ramis, Crainey, McArthur, McEachran, McManaman, Beausejour, Gomez, Fortune
Subs: Al Habsi, Barnett, Caldwell, Maloney, Espinoza, Collison, Powell
Arsenal: Fabianski, Sagna, Mertesacker, Vermaelen, Monreal, Arteta, Oxlade-Chamberlain, Ramsey, Cazorla, Podolski, Sanogo
Subs: Szczesny, Jenkinson, Gibbs, Kallstrom, Akpom, Eisfeld, Giroud