The French striker was left out of the side to face Crystal Palace in the Gunners' opening match of the new Premier League season on Saturday but, with Yaya Sanogo not travelling with the squad, Arsene Wenger has brought Giroud back into the fold.
Besiktas, meanwhile, start with Demba Ba up front after the former Chelsea man scored a hat-trick in their win over Feyenoord in the last round.
Besiktas: Zengin; Koybasi, Franco, Gulum, Motta, Ozyakup, Uysal, Kavlak, Sahan, Pektemek, Ba
Subs: Gonen, Kurtulus, Sivok, Frei, Tosun, Boral, Tore
© Getty Images
Arsenal: Szczesny; Debuchy, Chambers, Koscielny, Monreal; Arteta, Wilshere; Ramsey, Alexis, Cazorla; Giroud
Subs: Martinez, Oxlade-Chamberlain, Bellerin, Miquel, Campbell, Flamini, Rosicky
You can follow Sports Mole's live coverage of tonight's Champions League qualifier here.