The Gunners, who are currently at the top of the Premier League table, have won their last nine consecutive matches in all competitions.
Both sides won their opening fixtures in this season's Champions League, beating Marseille and Borussia Dortmund respectively.
Plenty of focus at the Emirates Stadium is likely to be on Gonzalo Higuain, who nearly joined Arsenal over the summer before signing with the Italians.
Possible starting lineups
Arsenal: Szczesny; Sagna, Mertesacker, Koscielny, Gibbs; Gnabry, Ramsey, Flamini Wilshere; Ozil; Giroud
Napoli: Reina; Mesto, Albiol, Britos, Zuniga; Callejon, Inler, Pandev, Behrami, Insigne; Higuain
Sports Mole says: 2-2