The French side have endured a miserable debut in Europe's elite club competition, picking up just one point from four games.
Meanwhile, the Gunners are second in Group B, one point behind Schalke 04 and one point ahead of Olympiakos, who meet each other in Germany.
If both Arsenal and Schalke win, then they will book their place in the last 16 with a game to spare.
Arsenal triumphed last time these sides met in September.
Possible starting lineups:
Arsenal: Mannone; Sagna, Mertesacker, Koscielny, Vermaelen; Arteta, Cazorla, Wilshere, Walcott, Podolski; Giroud
Montpellier: Jourdren; Bocaly, Hilton, Bedimo, Congre; Mounier, Belhanda, Cabella, Saihi; Utaka, Camara
Sports Mole says: 4-0