The Barcelona forward scored the winner against Brazil on his return from a three-month ban, although he may not get the chance to increase his international tally amid fears that Monday's game could be cancelled due to fighting between Israeli and Palestinian forces.
For Messi, it was fitting that his first game back for Argentina after returning from suspension came against Brazil, whose victory in last summer's Copa America he described as "fixed".
Those comments led to three months away from international action, serving as another blow to Argentinian football, but his winner against their old enemy gave La Albiceleste a rare moment of joy.
Indeed, following a second-round exit at last year's World Cup and a defeat to Brazil in the Copa America semi-final, there are doubts over Argentina's ability to assert themselves at major tournaments in the same way that they did across the 1980s and 1990s.
While the influence of Messi is often salutary, the 32-year-old's presence can sometimes appear to have a stymying effect, with too much tactical emphasis on getting the ball to him and not enough focus on how Argentina can best function as a collective attacking unit.
With this idea in mind, the Argentina boss ought to take a look at Monday's opponents as inspiration for how one creates a stable base from which an intractable outfit can emerge.
While Argentina have made eight managerial changes since 2006, Uruguay boss Oscar Tabarez has quietly and efficiently remained at the helm for 13 years, overseeing three World Cup campaigns and five Copa Americas, emerging victorious in 2011.
For country with a population of under 3.5 million, Tabarez has always constructed his team on the basis of optimal resourcefulness - something manifested in the way that Uruguay defend with such solidity and unity.
Indeed, while Uruguay may not always thrill spectators with their performances, the fact that they have conceded more than once in a game on just one occasion since October 2018 serves to illustrate that Tabarez has never allowed for the team's levels to drop.
With Luis Suarez and Edinson Cavani leading the counter-attacking effort, the two-time World Cup winners know their game-plan as if it were religious doctrine, making them a difficult opponent for any team to face.
Recent Argentina form: WDWDWW
Recent Uruguay form (all competitions): LWDWDW
For Uruguay, Cavani and Suarez are both expected to start up front once again, with the latter coming off at half time and the former scoring during the 2-1 win over Hungary last time out.
Moreover, Juventus midfielder Rodrigo Bentancur looks likely to make way for Arsenal's Lucas Torreira, whose performances for his national side played an important part in the club's decision to sign him last year.
Argentina possible starting lineup:
Musso; Foyth, Pezzella, Otamendi, Tagliafico; Rodriguez, Paredes, Acuna, Dybala; Aguero, Messi
Uruguay possible starting lineup:
Muslera; Gonzalez, Coates, Godin, Laxalt; Pereiro, Torreira; Lozano, Stuani; Cavani, Suarez
We say: Argentina 1-0 Uruguay
Provided that the bombs stay away, expect a cagey affair in Tel Aviv, with Uruguay players ganging up on Messi and any other pockets of space that Argentina find.
However, Argentina's six-game unbeaten streak, combined with the presence of Messi accompanied by Sergio Aguero, should be enough for Scaloni's side to snatch a winning goal.
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