Seedorf could hand a debut to 15-year-old midfielder Hachim Mastour, who starts on the bench for Milan.
Domenico Berardi leads the line for the visitors this evening and he notched four goals in the previous meeting between the two sides earlier this season. He is partnered by Simone Zaza and Nicola Sansone in attack for Sassuolo.
Milan: Abbiati, De Sciglio, Rami, Mexes, Constant; Montolivo, De Jong, Muntari, Taarabt, Pazzini, Kaka
Subs: Amelia, Coppola, Zaccardo, Zapata, Emanuelson, Essien, Poli, Honda, Balotelli, Mastour, Petagna, El Shaarawy
Sassuolo: Pomini, Mendes, Cannavaro, Ariaudo, Longhi, Chibsah, Magnanelli, Missiroli, Berardi, Zaza, Sansone
Subs: Polito, Pucino, Antei, Terranova, Gazzola, Rosi, Marrone, Biondini, Brighi, Masucci, Sanabria, Floro Flores