Cassano left the Rossoneri for Inter in the summer and is set to feature against his former club in the Derby della Madonnina at San Siro.
"A hostile reaction will not be a problem [for Cassano]," Milito told La Gazzetta dello Sport. "On the contrary, they will be doing him a great favour.
"He just gets fired up under such conditions. If he is feeling any nerves, he is certainly hiding it very well, joking and smiling during training, just being himself.
"He just has too much experience to be troubled with situations such as these."
Inter are currently third in Serie A with 12 points from six matches, five points ahead of Milan.