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41-year-old Reid threatened to cause an upset in the early stages, landing body shots consistently to keep Anderson on the defensive.
Reid's focus on attacking the body backfired in round four when one stray blow too many forced the referee to take a point away from the veteran.
Anderson turned on the accelerator in the fifth to set a pace that Reid simply could not match.
'The Widowmaker' landed a flush uppercut, which took Reid down to one knee for a brief period.
Reid got back to his feet and swung wildly, leaving Anderson with a target he punished consistently to bring the contest to an end.
A credible victory ends a frustrating year on a high for Anderson and makes him Scotland's only current holder of the famous Lonsdale strap.